Hemp grown for industrial purposes may be treated with harsh chemicals and solvents in the manufacturing process, leaving any resulting hemp oil unfit for consumption. Because our hemp is grown in ideal conditions to produce our CBD hemp oil supplements, we never use harmful chemicals in our extraction process. Instead, we extract our hemp oil using supercritical CO2, which the FDA considers GRAS or generally regarded as safe. This chemical process allows us to ensure that our CBD hemp oil supplements are always free from contamination to best protect the health of your family.
Food and beverage products containing CBD were introduced in the United States in 2017.[dubious – discuss][47] Hemp seed ingredients which do not naturally contain THC or CBD (but which may be contaminated with trace amounts on the outside during harvesting) were declared by the FDA as GRAS in December 2018. CBD itself has not been declared GRAS, and under U.S. federal law is illegal to sell as a food, dietary supplement, or animal feed.[13] State laws vary considerably as non-medical cannabis and derived products have been legalized in some jurisdictions in the 2010s.
After our CBD hemp oil has been extracted, it is put through our rigorous Triple Lab Tested™ process that examines our hemp oil at three points in the manufacturing process, confirming CBD levels and ensuring it is free from contaminants like mold, mildew, toxins, and heavy metals. Our CBD hemp oil is then formulated into our line of award-winning hemp oil supplements or packaged for bulk sale.
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After our CBD hemp oil has been extracted, it is put through our rigorous Triple Lab Tested™ process that examines our hemp oil at three points in the manufacturing process, confirming CBD levels and ensuring it is free from contaminants like mold, mildew, toxins, and heavy metals. Our CBD hemp oil is then formulated into our line of award-winning hemp oil supplements or packaged for bulk sale.

Pioneers of the CBD industry, 4 Corners Cannabis helped pave the way for companies that want to provide quality products and utilize best practices. They grow their own strain of hemp and make small batches of true full-spectrum CBD products. Their prices place them lower down on our ranking, but their highly satisfied customers are more than willing to pay for the 4 Corners quality.  
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
Cannabidiol has low affinity for the cannabinoid CB1 and CB2 receptors,[26][27] although it can act as an antagonist of CB1/CB2 agonists despite this low affinity.[27] Cannabidiol may be an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[28] It also may act as an inverse agonist of GPR3, GPR6, and GPR12.[29] CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist.[30] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[31] The pharmacological effects of CBD may involve PPARγ agonism and intracellular calcium release.[7] cannabidiol
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